Immunobiology - NUS Medical Sciences Cluster

 

Our Mission

To understand how the immune system functions in protection from infectious disease and cancer, how it can cause disease in allergy and autoimmunity, and to discover and develop ways to improve disease outcomes.

 

Who we are

We are researchers with academic homes in the Departments of Microbiology and Immunology, Physiology, and Paediatrics. Many of us also are a part of the LSI Immunology Programme based in the Center for Life Sciences. We have a very diverse scientific and technical background to bring to bear on the questions of Immunology.

 

What We Do

Our research is focused on the following areas:

 

  • Immune cell signaling
  • Antibody, protein, and cell engineering for therapy
  • Cancer immunotherapy, cancer vaccines, cancer immunobiology and inflammation
  • Autoimmunity, particularly Systemic Lupus Erythematosus
  • Immune response in infectious disease
  • Innate immune system
  • Lymphatic system
  • Macrophage, Dendritic cell and lymphocyte biology

 

We are supported by wonderful infrastructure in the form of state-of-the-art flow cytometry and imaging cores, and the exceptional animal facility provided by NUS Comparative Medicine.

 

The Way Forward

The vision of our programme is to use discoveries from our labs to pave the way for improved treatment and diagnosis of infectious diseases, cancer, and autoimmunity. We will use the latest techniques, and bring together inter-disciplinary teams to reach these goals.

 

Faculty Involved in the MSC Immunobiology Program

Researcher Department Description of Research
Nicholas Gascoigne

(Facilitator)

Microbiology and Immunology T cell activation and development. T-cell specific molecules as targets of immunotherapy. CAR-T cell signaling in immunotherapy
Veronique Angeli

(Facilitator)

Microbiology and Immunology Focus on macrophage and lymphatic system biology in the context of inflammation, lipid disorders and cardiovascular diseases
Paul MacAry Microbiology and Immunology The MacAry laboratory specializes in Immune repertoire mapping, protein engineering, antibody discovery and therapeutic antibody development
Herbert Schwarz Physiology Immunomodulation in cancer and autoimmune disease. Tumor immunotherapy using vaccination and chimeric antigen receptors. Pathogenesis mechanisms in Multiple sclerosis and Lupus
Lina Lim Hsiu Kim Physiology Innate immune signaling pathways. Inflammation and cancer. Cross-talk between immune cells and cancer. Toll like receptors in cancer
Zhang Yongliang Microbiology and Immunology Immune signalling. Innate immunity. T helper cell biology
Lu Jinhua Microbiology and Immunology Molecular and cellular origins of antinuclear autoantibodies. Structure and autoimmunogenicity of the nucleolus. Immunotherapeutic targeting of autoreactive B cells
Sylvie Alonso Microbiology and Immunology Host-pathogen interactions; animal models of infectious diseases; Focus on dengue, HFMD and tuberculosis
Liu Haiyan Microbiology and Immunology Immune regulation in the tumour microenvironment, tumour vaccine and adoptive immunotherapy
Makoto Yawata Paediatrics Human natural killer cell biology. Development of mechanisms for cellular immunotherapy
Benoit Malleret Microbiology and Immunology Immune cross-talk between the erythroid compartment and the innate immune system during bacterial infections
Koh Dow Rhoon Physiology Autoimmunity of lupus and rheumatoid arthritis