Metabolic and Cardiovascular Diseases - NUS Medical Sciences Cluster

  

Our Mission

We are a group of researchers who contribute our diverse expertise, ranging from lipid biochemistry to materials engineering and tissue regeneration, towards a unified, multidisciplinary platform that aims to improve scientific knowledge and outcomes in metabolic and cardiovascular diseases. We will concentrate on our strengths, which include deep understanding of materials engineering, epidemiological genetics and technical analytics such as mass spectrometry. The programme will couple these efforts with the goals of the Singapore Ministry of Health to create major epidemiological impact on the ageing societies in Singapore and around the world.

Who We Are

Our research focuses include the following:

  1. Discovering biomarkers of CVD;
  2. Evaluating novel platelet targets in the treatment of arterial thrombosis;
  3. Applying microengineering and materials engineering to new solutions for CVD;
  4. Regenerating heart tissue by tissue engineering of heart muscle cells;
  5. Characterising lipid profiles in health and disease (lipidomics);
  6. Studying the role of lipid metabolism and signalling in different diseases; and
  7. Role of nutritionally regulated genes in metabolism as well as lipid and nutrient transport

The research is supported by shared platforms such as the mass spectrometry facility at the Department of Biochemistry and the lipid detection and characterisation resources of the Singapore Lipidomics Incubator (SLING).

Faculty Involved in the MSC Metabolic and Cardiovascular Diseases Programme

Researcher Department Description of Research
Markus Wenk (Facilitator) Biochemistry Lipidomics, metabolomics, mass spectrometry
Chester Drum (Facilitator) Biochemistry Biomarkers of heart failure, mass spectrometry, materials engineering, clinical trials of novel diagnostic technologies
Thilo Hagen Biochemistry Cell metabolism, insulin receptor signalling
Nam Long Nguyen Biochemistry Lipid transporters, metabolic disease
Jiang Jianming Biochemistry Cardiac reprogramming and regeneration, hypertrophic and dilated cardiomyopathy, gene therapy
Veronique Angeli Microbiology & Immunology Lymphatic vessels, blood vessels, macrophages, atherosclerosis
Hanry Yu Physiology Regenerative medicine, in vitro liver diseases models, tissueomics, digital pathology of liver and gastrointestinal diseases, organs on chip, physiology of bile canaliculi and canals of herring

 

The Drum lab has engineered heat-stable protein “exoshells” that promote folding and stabilization of proteins. The figure shows surface representations of: (a) the empty exoshell, (b) the exoshell encapsulating green fluorescent protein, (c) the exoshell encapsulating horseradish peroxidase isoenzyme C, and (d) the exoshell encapsulating the luciferin 2-monooxygenase enzyme from the sea pansy Renilla. [Article in press, Nature Communications].

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