Running Against Resistance: The SPRINT-TB Research Programme
This passage could have described many people suffering from tuberculosis (TB) up to the 1940s, when the antibiotic streptomycin was discovered. Despite more TB drugs being available today, TB remains a leading cause of death from infection. This is mostly because of the long and inefficient courses of treatment that are hard to administer and difficult for patients to stick to.
New Hybrid Drug Plugs the Hole in Malaria Drug Resistance
A combination of artemisinin and another drug (artemisinin combination therapy, ACT) is currently the best malaria treatment recommended by the World Health Organization. In early 2015, artemisinin-resistant malaria was confirmed in five countries in Southeast Asia: Cambodia, Laos, Myanmar, Thailand, and Vietnam.
New Genetic Test Helps Doctors Adjust Dose of Potentially Toxic Drug in Asian Patients
Agnes (not her real name) is a typical 7-year-old in Primary 1, except for one thing: she has acute lymphoblastic leukaemia (ALL). She is also extremely sensitive to the common ALL drug 6-mercaptopurine (6-MP) and its toxic side effects. Shortly after starting treatment with 6-MP, Agnes’ blood cell levels plunged, making her susceptible to repeated infections.
Finding New Genes Linked to Glaucoma, the Leading Cause of Permanent Blindness
All over the world, glaucoma is a serious disease that can lead to irreversible blindness. In Singapore, it causes 60% of adult blindness in the Chinese population. Now, several large collaborations anchored by NUS Medicine researchers are helping to figure out the genes involved in this potentially devastating disease.
Nuclear DNA Gets Cut and Activates Immune System to Attack Cancer Cells
The conventional wisdom about cancer cells is that they are masters of camouflage, invisible to the immune system.