Sik Yin, Roger Foo

Foo Sik Yin, Roger

Appointment(s)
  • Professor, Department of Medicine
  • Senior Consultant, Division of Cardiology, National University Heart Centre, National University Health System
Joint Appointment(s)
  • Senior Group Leader, Genome Institute of Singapore, A*STAR
  • Senior Investigator, Genome Institute of Singapore, A*STAR
Academic Qualifications
  • MD, National University of Singapore, Singapore
  • MBBS, National University of Singapore, Singapore
  • FRCP, Royal College of Physicians, United Kingdom
  • FAHA, American Heart Association, USA
Research Interest(s)
  • Molecular Epigenetics
  • Chromatin Organisation
  • Cardiac Genomics and Epigenomics
  • Heart Failure
  • Genetics
Recent Publications
  • 1. Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy. Lim TB, Aliwarga E, Luu TDA, Li YP, Ng SL, Annadoray L, Sian S, Ackers-Johnson MA, Foo RS. Cardiovasc Res. 2019 May 22. pii: cvz130. doi: 10.1093/cvr/cvz130. [Epub ahead of print] PMID:31114845.
  • 2. Robust CTCF-Based Chromatin Architecture Underpins Epigenetic Changes in the Heart Failure Stress-Gene Response. Lee DP, Tan WLW, Anene-Nzelu CG, Lee CJM, Li PY, Luu TDA, Chan CX, Tiang Z, Ng SL, Huang X, Efthymios M, Autio MI, Jiang J, Fullwood MJ, Prabhakar S, Lieberman Aiden E, Foo RS. Circulation. 2019 Apr 16;139(16):1937-1956. doi: 10.1161/CIRCULATIONAHA.118.036726. PMID:30717603.
  • 3. Population genomics in South East Asia captures unexpectedly high carrier frequency for treatable inherited disorders. Bylstra Y, Kuan JL, Lim WK, Bhalshankar JD, Teo JX, Davila S, Teh BT, Rozen S, Tan EC, Liew WKM, Yeo KK, Tan P; SinGapore Incidental Finding (SGIF) study group, Saw SM, Cheng CY, Cook S, Foo R, Jamuar SS. Genet Med. 2019 Jan;21(1):207-212. doi: 10.1038/s41436-018-0008-6. Epub 2018 Jul 2. Erratum in: Genet Med. 2018 Dec;20(12):1692. PMID:29961769.
  • 4. Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling. Zhao RR, Ackers-Johnson M, Stenzig J, Chen C, Ding T, Zhou Y, Wang P, Ng SL, Li PY, Teo G, Rudd PM, Fawcett JW, Foo RSY. Circulation. 2018 Jun 5;137(23):2497-2513. doi: 10.1161/CIRCULATIONAHA.117.030353. Epub 2018 Jan 25. PMID:29371215.
  • 5. Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo. See K, Tan WLW, Lim EH, Tiang Z, Lee LT, Li PYQ, Luu TDA, Ackers-Johnson M, Foo RS. Nat Commun. 2017 Aug 9;8(1):225. doi: 10.1038/s41467-017-00319-8. PMID:28790305.