Hao Mang, Edward Koo

Koo Hao Mang, Edward

  • Professor, Department of Medicine
  • Professor, Department of Physiology
Academic Qualifications
  • MD, Duke University, USA
  • Board Certifications in Neurology, USA
  • Board Certifications in Neuropathology, USA
Research Interest(s)
  • Alzheimer's Disease
  • Cognition
  • Neurodegeneration
  • Cell and Molecular Biology
  • Synaptic Injury
Recent Publications
  • 1. Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. 2015 Dec. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). PLoS One. 10(12):e0144758. doi: 10.1371/journal.pone.0144758. 26678856.
  • 2. Nizetic D, Chen CL, Hong W, Koo EH. 2015 Dec. Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP. Front Behav Neurosci. 9:299. doi: 10.3389/fnbeh.2015.00299. 26648852.
  • 3. Tyan SH, Koo EH. 2015 Nov. New tricks from an old dog: Another synaptotoxic fragment from APP. Cell Res. 25(11):1185-6. doi: 10.1038/cr.2015.125. 26503171.
  • 4. Ling IF, Golde TE, Galasko DR, Koo EH. 2015 Aug. Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Alzheimers Res Ther. 7(1):55. doi: 10.1186/s13195-015-0137-y. 26244059.
  • 5. Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE. 2015 Jul. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Mol Neurodegener. 10:29. doi: 10.1186/s13024-015-0021-z. 26169917.