Xin Yuan Fu

Fu Xin Yuan

Appointment(s)
  • Professor, Department of Biochemistry, NUS Yong Loo Lin School of Medicine
  • Professor, Department of Biological Sciences, National University of Singapore
Administrative Appointment(s)
  • Director, International Relations (China), NUS Yong Loo Lin School of Medicine
  • Supervisor, NUS Graduate School for Integrated Sciences and Engineering
  • Senior Principal Investigator, Cancer Stem Cells Programme, Cancer Science Institute of Singapore, National University of Singapore
Academic Qualifications
  • Postdoctoral Training, Rockefeller University, USA
  • PhD, Columbia University, USA
Research Interest(s)
  • STAT3
  • Stem Cells
  • Tumorigenesis
  • Epigenetic
  • Tumor
Recent Publications
  • 1. Liu C, Zhang CW, Zhou Y, Wong WQ, Lee LC, Ong WY, Yoon SO, Hong W, Fu XY, Soong TW et al. 2017 Dec. APP upregulation contributes to retinal ganglion cell degeneration via JNK3. Cell Death and Differentiation. 1-16. doi: 10.1038/s41418-017-0005-3.
  • 2. Xu L, Liu X, Sheng N, Oo KS, Liang J, Chionh YH, Xu J, Ye F, Gao YG, Dedon PC et al. 2017 Jan. Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans. Journal of Biological Chemistry. 292(35):14695-14703. doi: 10.1074/jbc.M117.798298.
  • 3. Zhang ZY, Jiang M, Fang J, Yang MF, Zhang S, Yin YX, Li DW, Mao LL, Fu XY, Hou YJ et al. 2017 Jan. Enhanced Therapeutic Potential of Nano-Curcumin Against Subarachnoid Hemorrhage-Induced Blood–Brain Barrier Disruption Through Inhibition of Inflammatory Response and Oxidative Stress. Molecular Neurobiology. 54(1). doi: 10.1007/s12035-015-9635-y.
  • 4. Wang K, Fu XY, Fu XT, Hou YJ, Fang J, Zhang S, Yang MF, Li DW, Mao LL, Sun JY et al. 2016 Sep. DSePA Antagonizes High Glucose-Induced Neurotoxicity: Evidences for DNA Damage-Mediated p53 Phosphorylation and MAPKs and AKT Pathways. Molecular Neurobiology. 53(7):4363-4374. doi: 10.1007/s12035-015-9373-1.
  • 5. Huang W, Dong Z, Chen Y, Wang F, Wang CJ, Peng H, He Y, Hangoc G, Pollok K, Sandusky G et al. 2016 Feb. Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo. Oncogene. 35(6):783-792. doi: 10.1038/onc.2015.215.