Hao Mang, Edward Koo

Koo Hao Mang, Edward

Appointment(s)
  • Professor, Department of Medicine
  • Professor, Department of Physiology
Academic Qualifications
  • MD, Duke University, USA
  • Board Certifications in Neurology, USA
  • Board Certifications in Neuropathology, USA
Research Interest(s)
  • Alzheimer's Disease
  • Cognition
  • Neurodegeneration
  • Cell and Molecular Biology
  • Synaptic Injury
Recent Publications
  • 1. Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL et al. 2018 Jan. Short Aβ peptides attenuate Aβ42 toxicity in vivo. Journal of Experimental Medicine. 215(1):283-301. doi: 10.1084/jem.20170600.
  • 2. Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE et al. 2018 Jan. Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cellular and Molecular Life Sciences. 75(2):301-322. doi: 10.1007/s00018-017-2625-7.
  • 3. Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN et al. 2017 Nov. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Reports. 21(9):2614-2627. doi: 10.1016/j.celrep.2017.11.009.
  • 4. Lee LC, Goh MQL, Koo EH. 2017 Sep. Transcriptional regulation of APP by apoE: To boldly go where no isoform has gone before: ApoE, APP transcription and AD: Hypothesised mechanisms and existing knowledge gaps. BioEssays. 39(9). doi: 10.1002/bies.201700062.
  • 5. Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller UC et al. 2017 May. APLP1 is a synaptic cell adhesion molecule, supporting maintenance of dendritic spines and basal synaptic transmission. Journal of Neuroscience. 37(21):5345-5365. doi: 10.1523/JNEUROSCI.1875-16.2017.