Zhi Xiong Chen

Chen Zhi Xiong

  • Senior Lecturer, Department of Physiology
Administrative Appointment(s)
  • Assistant Dean of Students, Office of Student Affairs, National University of Singapore
  • Deputy Education Director, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore
  • Resident Fellow, King Edward VII Hall, National University of Singapore
  • Integration Lead Educator, NUS Yong Loo Lin School of Medicine
  • Physiology Deputy Programme Director, Medicine, NUS Yong Loo Lin School of Medicine
  • Physiology Deputy Programme Director, Dentistry, NUS Yong Loo Lin School of Medicine
  • House Mentor, NUS Yong Loo Lin School of Medicine
  • CenMED Associate, Centre for Medical Education, Yong Loo Lin School of Medicine
  • NCIS Affiliate, National University Cancer Institute, Singapore
Joint Appointment(s)
  • Joint Scientist, KK Women’s and Children’s Hospital, Singapore
Academic Qualifications
  • PhD, NUS Graduate School for Integrative Sciences and Engineering, Singapore
  • MHPE, Maastricht University, Netherlands
  • BSc (Honours), National University of Singapore, Singapore
  • Certificate of Completion in Medical and Health Professions Education, NUS CenMed, Singapore
Research Interest(s)
  • Neuroblastoma
  • Cancer Predisposition Genes
  • Circulating Tumour Cells
  • Paediatrics Solid Tumours
  • Drug Study
  • Graduate Education
  • Evaluation of Teaching-Learning
  • Faculty Support and Development
Recent Publications
  • 1. Angelina C, Tan ISY, Choo Z, Lee OZJ, Pervaiz S, Chen ZX. 2017 Dec. KIF1B beta increases ROS to mediate apoptosis and reinforces its protein expression through O-2(-) in a positive feedback mechanism in neuroblastoma. Scientific Reports. 7:16867. doi:10.1038/s41598-017-17192-6.
  • 2. Cai W, Chen ZX, Rane G, Singh SS, Choo Z, Wang C, Yuan Y, Tan TZ, Arfuso F, Yap CT et al. 2017 Jun. Wanted DEAD/H or Alive: Helicases Winding Up in Cancers. J Natl Cancer Inst. 109 (6). doi: 10.1093/jnci/djw278. 28122908.
  • 3. Choo Z, Koh RY, Wallis K, Koh TJ, Kuick CH, Sobrado V, Kenchappa RS, Loh AH, Soh SY, Schlisio S, Chang KT, Chen ZX. 2016 Jun. XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Oncotarget. 7(23):34229-39. doi: 10.18632/oncotarget.8748.
  • 4. Li S, Fell SM, Surova O, Smedler E, Wallis K, Chen ZX, Hellman U, Johnsen JI, Martinsson T, Kenchappa RS, Uhlén P, Kogner P, Schlisio S. 2016 Jan. The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis. Dev Cell. 36(2):164-78. doi: 10.1016/j.devcel.2015.12.029.
  • 5. Chen ZX, Wallis K, Fell SM, Sobrado VR, Hemmer MC, Ramsköld D, Hellman U, Sandberg R, Kenchappa RS, Martinson T, Johnsen JI, Kogner P, Schlisio S. 2014 Apr. RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma. Cancer Discov. 4(4):434-51. doi: 10.1158/2159-8290.CD-13-0362.