Catherine Ong

Ong Catherine

  • Assistant Professor, Department of Medicine
  • Consultant, Division of Infectious Diseases, University Medicine Cluster, National University Health System
Joint Appointment(s)
  • Visiting Consultant, Tuberculosis Control Unit, Tan Tock Seng Hospital, Singapore
Academic Qualifications
  • MBBS, National University of Singapore, Singapore
  • MRCP, Member of Royal College of Physicians, United Kingdom |MMed (Int Med), National University of Singapore, Singapore
  • PhD, Imperial College London, United Kingdom
  • FAMS, Fellow of the Academy Medicine, Singapore
Research Interest(s)
  • Tuberculosis
  • Host-pathogen interactions
  • Biomarker discovery
  • Host-directed therapy
  • Rapid pathogen detection
  • Antimicrobial resistance
Recent Publications
  • 1. S Brilha, CWM Ong, B Weksler, N Romero, P Couraud, and J Friedland. 2017 Nov. Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impairs blood-brain barrier function in an in vitro culture-based CNS TB model. Scientific Reports. 7:16031. doi:10.1038/s41598-017-16250-3.
  • 2. CWM Ong, P Elkington, JS Friedland. 2017 Feb. Tuberculosis, pulmonary cavitation and matrix metalloproteinases. American Journal of Respiratory and Critical Care Medicine. 190: 9-18. doi: 10.1164/rccm.201311-2106PP.
  • 3. CWM Ong, PJ Pabisiak, S Brilha, P Singh, F Roncaroli, PT Elkington, JS Friedland. 2017 Feb. Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. J Neuroinflammation. 14:31. doi: 10.1186/s12974-017-0801-1.
  • 4. Pabisiak, RC Moores, T Sathyamoorthy, V Patel, RH Gilman, JC Porter, JS Friedland. 2015 May. Neutrophil-derived MMP-8 drives AMPK-dependent matrix destruction in human pulmonary tuberculosis. PLOS Pathogens. 21;11(5):e1004917. doi: 10.1371/journal.ppat.1004917.
  • 5. Fry, P Elkington, F Roncaroli, P Elkington, J Friedland. 2011 May. Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways. Journal of Neuroinflammation. 8:46. doi: 10.1186/1742-2094-8-46.