Mahmoud Pouladi

Pouladi Mahmoud

  • Assistant Professor, Department of Medicine
Joint Appointment(s)
  • Associate Director, Translational Laboratory in Genetic Medicine, A*STAR
  • Principal Investigator, Translational Laboratory in Genetic Medicine, A*STAR
Academic Qualifications
  • PhD (Medical Genetics), University of British Columbia, Canada
  • MSc (Immunology), McMaster University, Canada
  • BSc (Molecular Biology), McMaster University, Canada
Research Interest(s)
  • Dementia
  • Huntington Disease
  • Fragile X Syndrome
  • Disease Modelling
  • Human Pluripotent Stem Cells
  • Target Discovery and Validation
Recent Publications
  • 1. Garcia-Miralles M, Hong X, Tan LJ, Caron NS, Huang Y, To XV, Lin RY, Franciosi S, Papapetropoulos S, Hayardeny L, Hayden MR, Chuang KH, Pouladi MA. Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease. Sci Rep. 2016 Aug 16;6:31652. doi: 10.1038/srep31652. PubMed PMID: 7528441; PubMed Central PMCID: PMC4985819.
  • 2. Teo RT, Hong X, Yu-Taeger L, Huang Y, Tan LJ, Xie Y, To XV, Guo L, Rajendran R, Novati A, Calaminus C, Riess O, Hayden MR, Nguyen HP, Chuang KH, Pouladi MA. Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease. Hum Mol Genet. 2016 Jul 1;25(13):2621-2632. PubMed PMID: 27126634; PubMed Central PMCID: PMC5181633.
  • 3. Garcia-Miralles M, Ooi J, Ferrari Bardile C, Tan LJ, George M, Drum CL, Lin RY, Hayden MR, Pouladi MA. Treatment with the MAO-A inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of Huntington disease. Exp Neurol. 2016 Apr;278:4-10. doi: 10.1016/j.expneurol.2016.01.019. PubMed PMID: 26825854.
  • 4. Ooi J, Hayden MR, Pouladi MA. Inhibition of Excessive Monoamine Oxidase A/B Activity Protects Against Stress-induced Neuronal Death in Huntington Disease. Mol Neurobiol. 2015 Dec;52(3):1850-61. doi: 10.1007/s12035-014-8974-4. PubMed PMID: 25398695; PubMed Central PMCID: PMC4586002.
  • 5. Pouladi MA, Morton AJ, Hayden MR. Choosing an animal model for the study of Huntington's disease. Nat Rev Neurosci. 2013 Oct;14(10):708-21. doi: 10.1038/nrn3570. Review. PubMed PMID: 24052178.