Alan Prem Kumar

Kumar Alan Prem

  • Research Assistant Professor, Department of Pharmacology
  • Research Assistant Professor, Cancer Science Institute of Singapore, National University of Singapore
Joint Appointment(s)
  • John Knott Cancer Fellow, Cancer Council Western Australia, Australia
  • Adjunct Principal Research Fellow (Associate Professor), School of Biomedical Sciences, Curtin University, Australia
  • Adjunct Associate Professor, Department of Biological Sciences, University of North Texas, USA
Academic Qualifications
  • PhD, University of North Texas, USA
  • BSc, University of North Texas, USA
  • MSc, University of North Texas, USA¬†
Research Interest(s)
  • Breast Cancer Biology
  • Breast Cancer Pharmacology
  • Breast Cancer Biotherapy
Recent Publications
  • 1. Shrimali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Ahn KS, Sethi G. 2013 Dec. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. Cancer Lett. 341(2):139-49. doi: 10.1016/j.canlet.2013.08.023. 23962559.
  • 2. Li F, Shanmugam MK, Chen L, Chatterjee S, Basha J, Kumar AP, Kundu TK, Sethi G. 2013 Aug. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signaling cascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 6(8):843-54. doi: 10.1158/1940-6207.CAPR-13-0070. 23803415.
  • 3. Subramaniam A, Loo SY, Rajendran P, Manu KA, Perumal E, Li F, Shanmugam MK, Siveen KS, Park JI, Ahn KS, Hui KM, Kumar AP, Sethi G. 2013 Oct. An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins. Apoptosis. 18(10):1175-87. doi: 10.1007/s10495-013-0851-5. 23700228.
  • 4. Zhu Y, Casey PJ, Kumar AP, Pervaiz S. 2013 Apr. Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. Cell Death Dis. 4:e568. doi: 10.1038/cddis.2013.103. 23559002.
  • 5. Shanmugam MK, Dai X, Kumar AP, Tan BK, Sethi G, Bishayee A. 2013 Jun. Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies. Biochem Pharmacol. 85(11):1579-87. doi: 10.1016/j.bcp.2013.03.006. 23499879.