Leilei Chen

Chen Leilei

Appointment(s)
  • Assistant Professor, Department of Anatomy
Administrative Appointment(s)
  • Principal Investigator, Cancer Science Institute of Singapore, National University of Singapore
Academic Qualifications
  • PhD, The University of Hong Kong, China
  • MD, Jiangsu University, China
Research Interest(s)
  • RNA Editing
  • Post-transcriptional Regulation
  • Cancer Biology
Recent Publications
  • 1. Chow RKK, Tsz-Kwan Sin S, Liu M, Li Y, Man Chan TH, Song Y, Chen L, Lai Wan Kwong D, Guan XY. 2017 Oct. AKR7A3 suppresses tumorigenicity and chemoresistance in hepatocellular carcinoma through attenuation of ERK, c-Jun and NF-κB signaling pathways. Oncotarget. 8(48):83469-83479. doi: 10.18632/oncotarget.12726.
  • 2. Qi L, Song Y, Chan THM, Yang H, Lin CH, Tay DJT, Hong H, Tang SJ, Tan KT, Huang XX et al. 2017 Jul. An RNA editing/dsRNA binding-independent gene regulatory mechanism of ADARs and its clinical implication in cancer. Nucleic Acids Research. doi: 10.1093/nar/gkx667.
  • 3. Chan THM, Qamra A, Tan KT, Guo J, Yang H, Qi L, Lin JS, Ng VHE, Song Y, Hong H et al. 2016 Oct. ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer. Gastroenterology. 151(4):637-+(24). doi: 10.1053/j.gastro.2016.06.043.
  • 4. Liu M, Chen L, Ma NF, Chow RKK, Li Y, Song Y, Chan THM, Fang S, Yang X, Xi S et al. 2016 May. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology. 63(5):1544-1559. doi: 10.1002/hep.28437.