Roshni Rebecca Singaraja

Singaraja Roshni Rebecca

  • Assistant Professor, Department of Medicine
Joint Appointment(s)
  • Principal Investigator, A*STAR
Academic Qualifications
  • PhD, University of Amsterdam, The Netherlands
  • BSc (Hons), University of Waterloo, Canada
Research Interest(s)
  • Diabetes
  • Cardiovascular Disease
  • Lipid Metabolism
  • Bile Acids
  • Human Genetics
  • Target Identification and Validation
Recent Publications
  • 1. Paththinige, C. S., Rajapakse, J. R. D. K., Constantine, G. R., Sem, K. P., Singaraja, R. R., Jayasekara, R. W., & Dissanayake, V. H. W. (2018). Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia - A preliminary report. Lipids in Health and Disease, 17(1). doi:10.1186/s12944-018-0763-z
  • 2. Chevre, R., Trigueros-Motos, L., Castano, D., Chua, T., Corliano, M., Patankar, J. V., . . . Singaraja, R. R. (2018). Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice. FASEB JOURNAL, 32(7), 3792-3802. doi:10.1096/fj.201701084RR
  • 3. Trigueros-Motos, L., Van Capelleveen, J. C., Torta, F., Castao, D., Zhang, L. H., Chai, E. C., . . . Singaraja, R. R. (2017). ABCA8 regulates cholesterol efflux and high-density lipoprotein cholesterol levels. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(11), 2147-2155. doi:10.1161/ATVBAHA.117.309574
  • 4. Skotte, N. H., Sanders, S. S., Singaraja, R. R., Ehrnhoefer, D. E., Vaid, K., Qiu, X., . . . Hayden, M. R. (2017). Palmitoylation of caspase-6 by HIP14 regulates its activation. Cell Death and Differentiation, 24(3), 433-444. doi:10.1038/cdd.2016.139
  • 5. Sadananda, S. N., Foo, J. N., Toh, M. T., Cermakova, L., Trigueros-Motos, L., Chan, T., . . . Brunham, L. R. (2015). Targeted next-generation sequencing to diagnose disorders of HDL cholesterol. JOURNAL OF LIPID RESEARCH, 56(10), 1993-2001. doi:10.1194/jlr.P058891