Zhi Xiong Chen

Chen Zhi Xiong

  • Lecturer, Department of Physiology
Administrative Appointment(s)
  • Resident Fellow, King Edward VII Hall, National University of Singapore
  • Integration Lead Educator, NUS Yong Loo Lin School of Medicine
  • Physiology Deputy Programme Director, Department of Medicine, NUS Yong Loo Lin School of Medicine
  • Physiology Deputy Programme Director, Faculty of Dentistry, National University of Singapore
Joint Appointment(s)
  • Joint Scientist, KK Women’s and Children’s Hospital, Singapore
Academic Qualifications
  • PhD, NUS Graduate School for Integrative Sciences and Engineering, Singapore
  • BSc (Honours), National University of singapore, Singapore
Research Interest(s)
  • Neuroblastoma
  • Cancer Predisposition Genes
  • Circulating Tumour Cells
  • Gastric Cancer
  • miRNAs
  • Paediatrics Solid Tumours
Recent Publications
  • 1. Choo Z, Koh RY, Wallis K, Koh TJ, Kuick CH, Sobrado V, Kenchappa RS, Loh AH, Soh SY, Schlisio S, Chang KT, Chen ZX. 2016 Jun. XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis. Oncotarget. 7(23):34229-39. doi: 10.18632/oncotarget.8748. 27097110.
  • 2. Li S, Fell SM, Surova O, Smedler E, Wallis K, Chen ZX, Hellman U, Johnsen JI, Martinsson T, Kenchappa RS, Uhlén P, Kogner P, Schlisio S. 2016 Jan. The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis. Dev Cell. 36(2):164-78. doi: 10.1016/j.devcel.2015.12.029. 26812016.
  • 3. Chen ZX, Wallis K, Fell SM, Sobrado VR, Hemmer MC, Ramsköld D, Hellman U, Sandberg R, Kenchappa RS, Martinson T, Johnsen JI, Kogner P, Schlisio S. 2014 Apr. RNA helicase A is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma. Cancer Discov. 4(4):434-51. doi: 10.1158/2159-8290.CD-13-0362. 24469107.
  • 4. Low IC, Chen ZX, Pervaiz S. 2010 Sep. Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cells. Antioxid Redox Signal. 13(6):807-19. doi: 10.1089/ars.2009.3050. 20367277.
  • 5. Chen ZX, Pervaiz S. 2010 Mar. Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2. Cell Death Differ. 17(3):408-20. doi: 10.1038/cdd.2009.132. 19834492.