Nurulhuda Mustafa

Mustafa Nurulhuda

  • Senior Research Fellow, Department of Medicine
Academic Qualifications
  • PhD (Oncology), National University of Singapore, Singapore
  • BSc Biomedical Science (Honours), National University of Singapore, Singapore
Research Interest(s)
  • Experimental Therapeutics
  • Cancer Immunotherapy
  • Mechanisms of Resistance in Cancer
Recent Publications
  • 1. Chu-Farseeva, Y. -Y., Mustafa, N., Poulsen, A., Tan, E. C., Yen, J. J. Y., Chng, W. J., & Dymock, B. W. (2018). Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 158, 593-619. doi:10.1016/j.ejmech.2018.09.024.
  • 2. Shanmugam, M. K., Ahn, K. S., Lee, J. H., Kannaiyan, R., Mustafa, N., Manu, K. A., . . . Kumar, A. P. (2018). Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma. FRONTIERS IN PHARMACOLOGY, 9, 11 pages. doi:10.3389/fphar.2018.00365.
  • 3. Mustafa, N., Lee, J. X. T., Nee, H. F. A., Bi, C., Chung, T. -H., Hart, S., & Chng, W. J. (2017). VS-5584 mediates potent anti-myeloma activity via the upregulation of a class II tumor suppressor gene, RARRES3 and the activation of Bim. ONCOTARGET, 8(60), 101847-101864. doi:10.18632/oncotarget.21988.
  • 4. Yao, L., Mustafa, N., Tan, E. C., Poulsen, A., Singh, P., Minh-Dao, D. -T., . . . Dymock, B. W. (2017). Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat. JOURNAL OF MEDICINAL CHEMISTRY, 60(20), 8336-8357. doi:10.1021/acs.jmedchem.7b00678.
  • 5. Yang, E. G., Mustafa, N., Tan, E. C., Poulsen, A., Ramanujulu, P. M., Chng, W. J., . . . Dymock, B. W. (2016). Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines. JOURNAL OF MEDICINAL CHEMISTRY, 59(18), 8233-8262. doi:10.1021/acs.jmedchem.6b00157.