Lok To Sham

Sham Lok To

Appointment(s)
  • Assistant Professor, Department of Microbiology & Immunology
Academic Qualifications
  • PhD, Indiana University Bloomington, USA
  • MPhil, the Chinese University of Hong Kong, Hong Kong SAR
  • BSc, the Chinese University of Hong Kong, Hong Kong SAR
Research Interest(s)
  • Capsular polysaccharide biosynthesis in Streptococcus pneumoniae
  • Bacterial cell envelope biogenesis
  • Antibiotic development
Recent Publications
  • 1. Sham LT, Zheng S, Kruse AC, Bernhardt TG. 2018 Jun. Loss of Specificity Variants of WzxC Suggest that Substrate Recognition is Coupled with Transporter Opening in MOP-familly Flippases. Molecular Microbiology. In press. doi: 10.1111/mmi.14002.
  • 2. Zheng S, Sham LT, Brock K, Robins WP, Mekalanos JJ, Marks DS, Bernhardt TG, Kruse AC. 2018 Jun. Structure and Function of the lipid II flippase MurJ from Escherichia coli. PNAS. 115:6709-14. doi: 10.1073/pnas.1802192115.
  • 3. Chamakura KR, Sham LT, Davis RM, Min L, Cho HC, Ruiz N, Bernhardt TG, Young R. 2017 Nov. A viral protein antibiotic inhibits lipid II flippase. Nature Microbioloy. 2:1480-84. doi: 10.1038/s41564-017-0023-4.
  • 4. Meeske AJ, Sham LT, Kimsey H, Koo BM, Gross CA, Bernhardt TG, Rudner DZ. 2015 May. MurJ and a novel lipid II flippase are required for cell wall biogenesis in Bacillus subtilis. Proc Natl Acad Sci USA. 112:6437-42. doi: 10.1073/pnas.1504967112.
  • 5. Sham LT, Butler EK, Lebar MD, Kahne D, Bernhardt TG, Ruiz N. 2014 Jul. Bacterial cell wall. MurJ is the flippase of lipid-linked precursors of peptidoglycan biogenesis. Science. 345:220-2. doi: 10.1126/science.1254522.