Yunn Hwen Gan

Gan Yunn Hwen

Appointment(s)
  • Associate Professor, Department of Biochemistry
Administrative Appointment(s)
  • Supervisor, NUS Graduate School for Integrative Sciences and Engineering
  • Chairman, Institutional Biosafety Committee, National University of Singapore
  • Chairman, Faculty Research Awards Committee
Academic Qualifications
  • PhD, University of Wisconsin-Madison, USA
  • BSc (Hons), Purdue University, USA
Research Interest(s)
  • Bacterial Infection
  • Innate Immunity
  • Gut Microbiota
  • Glutathione
Recent Publications
  • 1. Wong J, Chen Y, Gan YH. 2015 Jul. Host Cytosolic Glutathione Sensing by a Membrane Histidine Kinase Activates the Type VI Secretion System in an Intracellular Bacterium. Cell Host Microbe. 18(1):38-48. doi: 10.1016/j.chom.2015.06.002. 26094804.
  • 2. Lim YT, Jobichen C, Wong J, Limmathurotsakul D, Li S, Chen Y, Raida M, Srinivasan N, MacAry PA, Sivaraman J, Gan YH. 2015 Feb. Extended loop region of Hcp1 is critical for the assembly and function of type VI secretion system in Burkholderia pseudomallei. Sci Rep. 5:8235. doi: 10.1038/srep08235. 25648885.
  • 3. Chen Y, Schröder I, French CT, Jaroszewicz A, Yee XJ, Teh BE, Toesca IJ, Miller JF, Gan YH. 2014 Aug. Characterization and analysis of the Burkholderia pseudomallei BsaN virulence regulon. BMC Microbiol. 14:206. doi: 10.1186/s12866-014-0206-6. 25085508.
  • 4. Gamage AM, Lee KO, Gan YH. 2014 Aug. Effect of oral N-acetyl cysteine supplementation in Type 2 diabetic patients on intracellular glutathione content and innate immune responses to Burkholderia pseudomallei. Microbes Infect. 16(8):661-71. doi: 10.1016/j.micinf.2014.07.007. 25088507.
  • 5. Teh BE, French CT, Chen Y, Chen IG, Wu TH, Sagullo E, Chiou PY, Teitell MA, Miller JF, Gan YH1. 2014 May. Type three secretion system-mediated escape of Burkholderia pseudomallei into the host cytosol is critical for the activation of NFκB. BMC Microbiol. 14:115. doi: 10.1186/1471-2180-14-115. 24884837.