Identification of disease-specific molecular landscapes for proper patient stratification is pivotal to the success of precision medicine. Up until recent years, RNA was implicated by Francis Crick’s central dogma as the key messenger between DNA and protein. With the advent of new technologies, we now know that the human genome encodes a vast repertoire of non-coding RNAs (ncRNAs), which was thought to be meaningless “dark matter”. Our current understanding of ncRNAs may look like an intertwined mess of molecules, but collectively they exhibit architecture and coordination, leading to elegantly choreographed regulation of DNA and protein expression/functions. While ncRNAs constitute more than 90 percent of the RNAs made from the human genome, most of the 30,000-plus known ncRNAs have been discovered in the past 10 years and are largely unstudied.
In this Symposium, we invite you to join a distinguished panel of overseas and local experts to discuss the utility of ncRNA-based diagnostics and therapeutics in the clinical management of human diseases, as well as to dissect the forms and functions of ncRNAs that play critical roles in defining the clinical trajectory of diverse human diseases.