Mahmoud Pouladi

Pouladi Mahmoud

  • Assistant Professor, Department of Medicine
Joint Appointment(s)
  • Associate Director, Translational Laboratory in Genetic Medicine, A*STAR
  • Principal Investigator, Translational Laboratory in Genetic Medicine, A*STAR
Academic Qualifications
  • PhD (Medical Genetics), University of British Columbia, Canada
  • MSc (Immunology), McMaster University, Canada
  • BSc (Molecular Biology), McMaster University, Canada
Research Interest(s)
  • Dementia
  • Huntington Disease
  • Fragile X Syndrome
  • Disease Modelling
  • Human Pluripotent Stem Cells
  • Target Discovery and Validation
Recent Publications
  • 1. Chia, P. H., Zhong, F. L., Niwa, S., Bonnard, C., Utami, K. H., Zhang, R., . . . Reversade, B. (2018). A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability. ELIFE, 7, 19 pages. doi:10.7554/eLife.32451
  • 2. Kusko, R., Dreymann, J., Ross, J., Cha, Y., Escalante-Chong, R., Garcia-Miralles, M., . . . Hayden, M. R. (2018). Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse. MOLECULAR NEURODEGENERATION, 13, 15 pages. doi:10.1186/s13024-018-0259-3
  • 3. Garcia-Miralles, M., Geva, M., Tan, J. Y., Yusof, N. A. B. M., Cha, Y., Kusko, R., . . . Pouladi, M. A. (2017). Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice.. JCI Insight, 2(23). doi:10.1172/jci.insight.95665
  • 4. Chen, M. Z., Moily, N. S., Bridgford, J. L., Wood, R. J., Radwan, M., Smith, T. A., . . . Hatters, D. M. (2017). A thiol probe for measuring unfolded protein load and proteostasis in cells. NATURE COMMUNICATIONS, 8, 11 pages. doi:10.1038/s41467-017-00203-5
  • 5. Takata, K., Kozaki, T., Lee, C. Z. W., Thion, M. S., Otsuka, M., Lim, S., . . . Ginhoux, F. (2017). Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function. IMMUNITY, 47(1), 183-+. doi:10.1016/j.immuni.2017.06.017